Regulation of Circadian Clocks by Redox Homeostasis

Circadian Clocks Running on Redox

Clock (CLK), is replaced by an analogous protein, D-80336 Munich NPAS2 (also called MOP4). Like CLK, it heterodimerizes Germany with BMAL1 (also called MOP3) to drive transcription of a collection of downstream effectors, including mper1, mper2, and mcry1. Further experiments demonstrate Andre Gide wrote: " If I were not there to make them that, like in the feedback loop where CLK and BMAL1 acq...

Transcriptional Regulation of Circadian Clocks

The first chapter of this book has introduced the historical background of the circadian clock, as well as its anatomical organization. It has described how researchers over the past several decades have grappled with the problem of biological timekeeping: how a constantly-changing organism can measure time, and in particular solar time, accurately in a changing environment? In the case of simp...

Circadian clocks, feeding time, and metabolic homeostasis

Metabolic processes exhibit diurnal variation from cyanobacteria to humans. The circadian clock is thought to have evolved as a time keeping system for the cell to optimize the timing of metabolic events according to physiological needs and environmental conditions. Circadian rhythms temporally separate incompatible cellular processes and optimize cellular and organismal fitness. A modern 24 h ...

Circadian clocks: from stem cells to tissue homeostasis and regeneration

The circadian clock is an evolutionarily conserved timekeeper that adapts body physiology to diurnal cycles of around 24 h by influencing a wide variety of processes such as sleep-to-wake transitions, feeding and fasting patterns, body temperature, and hormone regulation. The molecular clock machinery comprises a pathway that is driven by rhythmic docking of the transcription factors BMAL1 and ...

REGULATION OF ACID-BASE HOMEOSTASIS BY THE KIDNEY